Nicotinic acetylcholine receptor modulators
AssigneeAstraea Therapeutics, LLC
InventorsNurulain Zaveri, Faming Jiang, Lawrence Toll
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Abstract
Provided herein are novel and selective high affinity α3β4 nicotinic acetycholine receptor ligands and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, drug addiction or pain using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of selectively antagonizing receptors such as, for example, the α3β4 nicotinic acetycholine receptor using the compounds and compositions disclosed herein.
Claims22
A method of treating or preventing drug addiction in a patient comprising administering to the patient in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutical composition thereof:
- or salts, hydrates or solvates thereof wherein:
- R1 is hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl or substituted heteroarylalkyl;
- Y is —NR3;
- R3 is hydrogen, alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl or substituted heteroarylalkyl;
- and
- X is aryl, substituted aryl, heteroaryl or substituted heteroaryl.
Dependencies are inferred from the claim text.