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US 2015/0148540 A1Published application
Methods for the synthesis of tiotropium bromide
OwnerMahmut BILGICinventor
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Abstract
Present invention relates to methods for preparing (1α,2β,4β,5α,7β)-7-[(hydroxidi-2-thienllacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide.
Claims5
A synthesis method so as to be used in the synthesis of tiotropium bromide, wherein said method comprises transforming di-(2-thienyl)-acetic acid
- into formula 2C;
- obtaining scopine ester shown in formula 4C as a consequence of the reaction of the obtained acid anhydride with scopine;
- obtaining the compound demonstrated in formula 5C after the obtained scopine ester is quaternized with methyl bromide;
- then processing this compound obtained at the end with organic and/or inorganic basic substances and transforming it into tiotropium bromide.
1 more element
Dependencies are inferred from the claim text.