US 2015/0148352 A1 · COMPOSITIONS AND METHODS FOR THE TREATMENT ANGINA AND CARDIOVASCULAR CONDITIONS

Abstract

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of angina and cardiovascular conditions may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of chronic aneurysm, angina, atherosclerosis, cerebrovascular accident (stroke), cerebrovascular disease, congestive heart failure, coronary artery disease, myocardial infarction (heart attack), peripheral vascular disease, aortic dissection, aortic stenosis, arrhythmia (irregular heartbeat), atrial fibrillation, cardiomyopathy, chest pain, claudication, congenital heart disease.

Claims5

Dependent claims

A compound of Formula I:

or a pharmaceutically acceptable salt, hydrate, polymorph, solvate, prodrug, enantiomer, or stereoisomer thereof, wherein:
R1 represents H, D, null,
R2 represents
each n is independently 1, 2, 3, 4 or 5;
each a is independently 2, 3 or 7;
each b is independently 3, 5 or 6;
each e is independently 1, 2 or 6;
each c and each d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3;
R3 represents H, D, null,
R4 represents H, D,
R5 represents H, D, null,
each n is independently 1, 2, 3, 4 or 5;
each a is independently 2, 3 or 7;
each b is independently 3, 5 or 6;
each e is independently 1, 2 or 6;
and
each c and each d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3.

14 more elements

Dependencies are inferred from the claim text.

Compositions and methods for the treatment angina and cardiovascular conditions

Life of this patent

Compositions and methods for the treatment angina and cardiovascular conditions

Life of this patent

Abstract

Claims5