Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is hydrogen or (C1-C6)alkyl;
• R2 is optionally substituted 5-6 membered heteroaryl;
• phenyl ring A is optionally substituted;
• and
• R4 is selected from (C1-C6)alkyl, (C2-C6)alkenyl, and (C2-C6)alkynyl, each of which may be optionally substituted with one or more groups selected from —C(═O)ORa, —C(═O)NRaRb, —C(═O)Ra, —C(═NORa)Rb, —C(═NRa)NRbRa, —NRaC(═O)NRbRa, —NRaC(═O)Rb, —NRaC(═NRb)NRaRb, —NRaC(═O)ORb, —OC(═O)NRaRb, —OC(═O)Ra, —OC(═O)ORa, —S(O)0-3Ra, —SO2NRaRb, —NRaSO2Rb, —NRaSO2NRbRa, and —P(═O)ORaORb, wherein each Ra and Rb are independently hydrogen or (C1-C6)alkyl;
• provided that the compound of Formula I is not 2-(8-(6-aminopyridin-3-yl)-1-methyl-6-(4-(trifluoromethyl)phenyl)-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide, 2-(8-(6-aminopyridin-3-yl)-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide, or 2-(8-(6-aminopyridin-3-yl)-6-(4-fluorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide, or a pharmaceutically acceptable salt thereof.