Potentiation of antibiotic treatment with a protein-lipid complex
AssigneeThe Research Foundation for The State University of New York
InventorsAnders P. Hakansson, Laura R. Marks, Hazeline Hakansson
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Abstract
Provided are compositions and methods for potentiating the effect of antibiotics. The compositions comprise a non-covalent complex of alpha-lactalbumin and fatty acid. The fatty acids are cis, unsaturated, C14 to C20 fatty acids. The complex and antibiotic can be administered to an individual together or separately. The antibiotic may be one to which resistance has developed.
Claims20
A composition suitable for administration to an individual comprising:
- a) alpha-lactalbumin fatty acid complex, wherein the fatty acids in the complex comprise cis, unsaturated, C14, C16, C18 and/or C20 fatty acids;
- and
- b) an antibiotic,
- in a pharmaceutical carrier, wherein a) potentiates the action of the antibiotic for treatment of an infection in the individual.
A method of treating a bacterial infection in an individual comprising the steps of:
- a) providing a composition comprising alpha-lactalbumin complexed to fatty acids, wherein the fatty acids comprise cis, unsaturated, C14, C16, C18 and/or C20 fatty acids;
- b) administering to an individual the composition from a);
- and
- c) separately, or together with b), administering an antibiotic to the individual.
A kit for treatment of infections comprising:
- a) alpha-lactalbumin fatty acid complex in an amount suitable to act as an adjuvant;
- b) an antibiotic in an amount suitable to treat the infection in the presence of a);
- c) instructions for administration of a) and b), wherein a) and b) are administered separately or together via same or different routes.
Dependencies are inferred from the claim text.