Method for determining disease severity in tauopathy-related neurodegenerative disorders
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsTeresa Dianne Langford, Salim Merali
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Abstract
A method for determining disease severity in a subject afflicted with a tauopathy-related neurodegenerative disease comprises detecting the level of a PINCH protein or isoform thereof in a test sample comprising brain tissue or cerebrospinal fluid. The PINCH protein level in the test sample indicates the relative severity of the tauopathy-related neurodegenerative disease afflicting the subject.
Claims26
A method for determining disease severity in a subject afflicted with a tauopathy-related neurodegenerative disease comprising:
- detecting the level of a PINCH protein in a test sample comprising brain tissue or cerebrospinal fluid from a subject afflicted with a tauopathy-related neurodegenerative disease;
- comparing said level of said PINCH protein in said test sample with the level of said PINCH protein in at least one control sample;
- wherein the level of said PINCH protein in the test sample as compared to the level in the control sample indicates the relative severity of the tauopathy-related neurodegenerative disease afflicting the subject.
A method of monitoring the progression of a tauopathy-related neurodegenerative disease in a subject, said method comprising:
- obtaining a first test sample comprising brain tissue or cerebrospinal fluid from a subject afflicted with a tauopathy-related neurodegenerative disease at a first time point and a second test sample comprising brain tissue or cerebrospinal fluid from said subject at a second time point;
- detecting the level of a PINCH protein from said first and second test samples;
- and
- comparing the level of said PINCH protein determined in said first test sample to the level of said PINCH protein from said second test sample, wherein an elevated level, decreased or unchanged level of said PINCH protein in said second test sample relative to the level of said PINCH protein in said first sample is an indication that the a tauopathy-related neurodegenerative disease has worsened, diminished or remained unchanged in said subject.
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A method for determining disease severity in a subject afflicted with a disease condition comprising:
- detecting the level of a PINCH protein isoform in a test sample from a subject afflicted with a disease;
- comparing said level of said PINCH protein isoform in said test sample with the level of said PINCH protein isoform in at least one control sample;
- wherein the level of said PINCH protein isoform in the test sample as compared to the level in the control sample indicates the relative severity of the disease condition afflicting the subject.
Dependencies are inferred from the claim text.