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OwnerFrank Vollmer, Yuqiang Wu +1inventors
InventorsFrank Vollmer, Yuqiang Wu, David Zhang
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A sensor device (100), which is adapted for detecting target molecules having a target nucleic acid sequence, comprises an optical whispering gallery mode (WGM) resonator (10) having a resonance frequency, wherein the WGM resonator is functionalized with a double-strand DNA precursor compound and the 10 resonance frequency depends on a mass load provided by the double-strand precursor compound, the double-strand precursor compound is capable of a target-specific strand displacement reaction with the target molecules, and in response to the strand displacement reaction, the double-strand precursor 15 compound is capable to be partially decoupled from the WGM resonator (10), wherein the mass load can be decreased and the resonance frequency of the WGM resonator can be increased. Furthermore, a sensing method for detecting target molecules including nucleic acid sequences is described.
A sensor device, which is adapted for detecting target molecules having a target nucleic acid sequence, comprising:
The sensor device according to one of the foregoing claims, —the WGM resonator is provided with at least one optical waveguide or optical prism being arranged for at least one of in-coupling sample light into the WGM resonator and out-coupling resonator light out of the WGM resonator.
A sensing method for detecting target molecules including nucleic acid sequences, comprising:
Dependencies are inferred from the claim text.