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US 2015/0147406 A1Published application
Intraocular Formulation
AssigneeAllergan, Inc.
InventorsMichael R. Robinson, Wendy M. Blanda, Hui Liu, Scott M. Whitcup, Patrick M. Hughes
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Abstract
Biodegradable therapeutic agent incorporating microspheres formulated in a high viscosity carrier suitable for intraocular administration to treat an ocular condition. The formulation can also be used to treat non-ocular conditions such as articular pathologies
Claims8
A biocompatible, injectable intraocular drug delivery system comprising:
- (a) a plurality of biodegradable microspheres;
- (b) a therapeutic agent incorporated by the microspheres;
- and
- (c) a viscous carrier for the microspheres, the viscous carrier having a viscosity at 25° C. of between about 140,000 cps and about 500,000 cps at a shear rate of 0.1/second, thereby forming a biocompatible, injectable intraocular drug delivery system, wherein the viscous carrier is a partially crosslinked hyaluronic acid, and wherein the microspheres comprise a poly(lactide-co-glycolide) (PLGA) polymer, the drug delivery system such that about one hour after intravitreal injection of the drug delivery system about 5% or less of the microspheres are present in the vitreous free of the viscous carrier.
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Dependencies are inferred from the claim text.