Ledgf peptides and formulations thereof for treatment of degenerative disorders
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsUday B. Kompella, Rinku Baid, Arun K. Upadhyay, Sarath Yandrapu
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Abstract
LEDGF peptides with anti-protein aggregation activity and methods of use are provided. The LEDGF peptides disclosed herein demonstrate an ability to treat degenerative diseases and diseases with various cellular stresses including oxidative stress and protein-aggregation stress. In addition, extended release formulations, including formulations suitable for ophthalmic administration are provided.
Claims26
A peptide comprising an amino acid sequence of lens epithelium derived growth factor (LEDGF), wherein the peptide comprises a LEDGF N-terminal stress related binding domain.
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