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US 2015/0147398 A1Published application
Paliperidone Implant Formulation
AssigneeLaboratorios Farmaceuticos Rovi, S.A.
InventorsIbon GUTIERRO ADURIZ, Guillermo FRANCO RODRÍGUEZ
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AssigneeLaboratorios Farmaceuticos Rovi, S.A.
InventorsIbon GUTIERRO ADURIZ, Guillermo FRANCO RODRÍGUEZ
Estimating the term…
An injectable intramuscular depot composition suitable for forming an in situ solid implant in a body, comprising a drug which is paliperidone and/or its pharmaceutical acceptable salts in any combination thereof, a biocompatible copolymer based on lactic and glycolic acid having a monomer ratio of lactic to glycolic acid of about 50:50 and DMSO as solvent, wherein the composition releases the drug with an immediate onset of action and continuously for at least 8 weeks and wherein the composition has a pharmacokinetic profile in vivo suitable for the formulation to be administered each 8 weeks or even longer periods.
1) An injectable intramuscular depot composition suitable for forming an in situ solid implant in a body, comprising a drug which is paliperidone and/or its pharmaceutical acceptable salts in any combination thereof, a biocompatible copolymer based on lactic and glycolic acid having a monomer ratio of lactic to glycolic acid in the range from 45:55 to 55:45 and DMSO as solvent, wherein the composition releases the drug with an immediate onset of action and continuously for at least 8 weeks and wherein the composition has a pharmacokinetic profile in vivo suitable for the formulation to be administered each 8 weeks or longer periods, characterised in that the biocompatible copolymer has a molecular weight in the range of between 31 and 43 kDa and an inherent viscosity in the range of between 0.27-0.31 dl/g±10%.
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16) A method of administering paliperidone to a subject in need thereof, the method comprising:
17) The method of claim 19 comprising:
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19) A method of administering paliperidone to a subject in need thereof, the method comprising:
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21) A method of administering paliperidone to a subject in need thereof, the method comprising:
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47) A sustained release injectable depot composition comprising:
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Dependencies are inferred from the claim text.