Biomatrix Hydrogels and Methods of Use Thereof
AssigneeCartiheal (2009) Ltd.
InventorNir Altschuler
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Abstract
This invention is directed to aragonite and calcite hydrogel biomatrices, optionally seeded with precursor cells and uses thereof in tissue engineering, regeneration and repair, including in inducing or enhancing bone formation, cartilage formation or a combination thereof in a subject, and kits related thereto.
Claims87
A hydrogel biomatrix comprising a marine organism skeletal derivative biomatrix, wherein said marine organism skeletal derivative is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value wherein said fluid is water, or said fluid is a protein-containing, salt-containing or carbohydrate containing solution.
A method of tissue engineering, tissue regeneration or tissue repair in a subject comprising administering to said subject a hydrogel comprising a marine organism skeletal derivative biomatrix, wherein
- said marine organism skeletal derivative is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value;
- and
- said biomatrix is optionally seeded with a precursor cell, which can participate in said tissue engineering, tissue regeneration or tissue repair.
Dependencies are inferred from the claim text.