Pharmaceutical composition containing fimasartna and hydrochlorothiazide
AssigneeBoryung Pharmaceutical Co., Ltd.
InventorsJe Hak Kim, Kyung Wan Nam, Seo Hun Park, Ju Won Kim, Sang Yeop Kim
Life of this patent
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Abstract
The present invention provides: a pharmaceutical composition having a superior physical property since fimasartan and hydrochlorothiazide, which are main components of a combination preparation, have superior content uniformity; and a preparation method thereof.
Claims19
A pharmaceutical composition comprising:
- fimasartan, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof;
- hydrochlorothiazide, a pharmaceutically acceptable salt hereof, a hydrate thereof, or a solvate thereof;
- and
- a binder exhibiting a viscosity of 20 mPa·s to 1,000 mPa·s at 25° C.
A method of preparing a pharmaceutical composition comprising fimasartan, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof and hydrochlorothiazide, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, the method comprising the steps of:
- preparing a mixture comprising fimasartan, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof and hydrochlorothiazide, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof;
- preparing granules by mixing the mixture with a binding solution in which a binder is dissolved to exhibit a viscosity of 20 mPa·s to 1,000 mPa·s at 25° C.;
- and
- preparing an uncoated tablet containing the granules.
Dependencies are inferred from the claim text.