Materials and Methods for Modulating immune Responses
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsClive Henry Wasserfall, Mark A. Atkinson, Benjamin George Keselowsky, Young Mee Yoon
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Abstract
The present invention provides materials and methods for modulating an immune response. In one embodiment, the present invention provides an initial artificial lymph-node homing environment, and a simultaneous, or subsequent, artificial spleen environment leading to the resolution of the activated immune responses. In one specific embodiment, the present invention can be used to prevent and/or treat pathogenic infection, cancer, allergenic reactions, and/or unwanted immune or auto-immune responses.
Claims20
A method for inducing a protective immune response against a target antigen, autoantigen or allergen, wherein the method comprises administering, to a subject in need of such an immune response, a pro-inflammatory adjuvant and an anti-inflammatory adjuvant, wherein said method further comprises administering the target antigen, autoantigen or allergen.
A device for modulating an immune response in a subject, wherein said device comprises:
- a scaffold matrix made of biocompatible material, wherein the scaffold matrix comprises a pro-inflammatory agent, an anti-inflammatory agent, and an antigen, autoantigen, or allergen.
A device for modulating an immune response in a subject, wherein said device comprises:
- 1) a pro-inflammatory composition comprising:
- a scaffold matrix comprising:
- a) an immuno-modulating molecule that induces the migration of an immune cell,
- b) a pro-inflammatory agent, and
- c) a microparticle encapsulating therein, at least, an antigen, autoantigen, or allergen;
- and
- 2) an anti-inflammatory composition comprising a scaffold matrix, wherein the scaffold matrix comprises an anti-inflammatory agent;
- wherein the outer surface of the microparticle comprises one or more surface ligands that bind to the target immune cell.
Dependencies are inferred from the claim text.