Method of inducing antibodies to human immunodeficiency virus involving the administration of mper peptide-liposome conjugates
AssigneeDuke University
InventorsBarton F. HAYNES, S. Munir Alam, Hua-Xin Liao
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Abstract
The present invention relates to a method of inducing the production in a patient of anti-HIV antibodies. The method comprises administering to a patient in need thereof an amount of at least one liposome-peptide conjugate in an amount sufficient to effect that induction. The peptide comprises a membrane external proximal region (MPER) epitope and the liposome comprises lysophosphorylcholine or phosphatidylserine.
Claims4
An immunogenic composition comprising a peptide comprising an epitope of the human immunodeficiency virus type-1 (HIV-1) envelope gp41 membrane proximal region (MPER) and a linker, wherein the peptide is embedded in a liposome via the linker, and wherein said liposome comprises cholesterol.
Dependencies are inferred from the claim text.