Egfr antagonist for the treatment of heart disease
OwnerQingping FENG, Xiangru LUinventors
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Abstract
The present invention relates to the use of epidermal growth factor receptor (EGFR) antagonists in methods and compositions useful for the treatment of heart disease in a subject. In one embodiment, the methods of the present invention comprise: (a) administering to the subject an EGFR antagonist; and (b) inhibiting or substantially inhibiting the EGFR signal transduction cascade. In another embodiment the method of the present invention may be used in combination with another heart disease therapy.
Claims25
A method of treating a subject having heart disease and in need thereof wherein heart disease includes acute myocardial infarction, myocardial infarction, heart failure, systolic or diastolic heart failure, heart failure due to hypertension or diabetes, cardiomyopathy, ischemic cardiomyopathy or hypertrophic cardiomyopathy, the method comprising administering to the subject an epidermal growth factor receptor (EGFR) antagonist.
A method of inducing wound healing in a subject having heart disease wherein heart disease includes acute myocardial infarction, myocardial infarction, heart failure, systolic or diastolic heart failure, heart failure due to hypertension or diabetes, cardiomyopathy, ischemic cardiomyopathy or hypertrophic cardiomyopathy, said method comprising administering to the subject an effective amount of an EGFR antagonist.
Dependencies are inferred from the claim text.