Intravenous synthetic curcumin (s-curcumin) for the treatment of proliferative disorders
AssigneeSignpath Pharma, Inc.
InventorLawrence Helson
Life of this patent
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Abstract
Compositions and methods for the treatment of proliferative disorders including proliferative such as breast, uterine cervical, ophthalmic, and pancreatic cancer by the administration of intravenous synthetic curcumin (S-curcumin) are disclosed herein.
Claims30
A composition for ameliorating symptoms or treating one or more proliferative disorders in a subject comprising:
- one or more spherical liposomes comprising a lipid or a phospholipid wall, wherein the liposome encloses a synthetic curcumin (S-curcumin) or derivatives and modifications thereof dissolved or dispersed in an aqueous or a non-aqueous solvent with one or more optional related co-factors, proteins, antibodies, pain medications, and other pharmaceutically active agents dissolved, dispersed, or suspended in the solvent;
- a suitable aqueous or non-aqueous dispersion medium, wherein the one or more spherical liposomes are dispersed in the dispersion medium;
- and
- one or more optional excipients, diluents, extended or controlled release agents, lubricants, preservatives or any combinations thereof.
A composition for ameliorating symptoms or treating one or more proliferative disorders in a subject comprising:
- a biodegradable polymer conjugate dissolved or dispersed in a suitable aqueous or non-aqueous solvent, wherein the conjugate comprises a synthetic curcumin (S-curcumin) or derivatives and modifications thereof conjugated to one or more polymers selected from the group consisting of polyesters, polylactides, polyglycolides, polycaprolactones, polyanhydrides, polyamides, polyurethanes, polyesteramides, polydioxanones, polyacetals, polyketals, polycarbonates, polyorthocarbonates, polyorthoesters, polyphosphoesters, polyphosphazenes, polyhydroxybutyrates, polyhydroxyvalerates, polyalkylene oxalates, polyalkylene succinates, poly(malic acid), poly(amino acids), copolymers, terpolymers, and combinations or mixtures thereof;
- and
- one or more excipients, diluents, extended or controlled release agents, lubricants, preservatives or any combinations thereof.
A method of ameliorating symptoms or treating one or more proliferative disorders in a subject comprising the steps of:
- identifying the subject in need of amelioration of symptoms or treatment of the one or more proliferative disorders;
- and
- administering intravenously one or more pharmaceutical compositions comprising a therapeutically effective amount of a synthetic curcumin (S-curcumin) or derivatives and modifications thereof dissolved or dispersed in a suitable aqueous or non-aqueous medium, wherein the curcumin is enclosed in one or more spherical liposomes or is conjugated to one or more biodegradable polymers.
A composition for ameliorating symptoms or treating breast cancer in a human subject comprising synthetic curcumin (S-curcumin) or derivatives and modifications thereof dissolved or dispersed in a suitable aqueous or non-aqueous medium, wherein the S-curcumin is enclosed in one or more spherical liposomes or is conjugated to one or more biodegradable polymers.
A composition for ameliorating symptoms or treating at least one of proliferative disorders, neurological disorders, or neurodegenerative conditions, in a subject comprising:
- curcumin, synthetic curcumin (S-curcumin), curcumin analogues, curcumin derivatives or combinations thereof dissolved or dispersed in a suitable aqueous or non-aqueous medium, wherein the curcumin or the S-curcumin is enclosed in one or more spherical liposomes or is conjugated to one or more biodegradable polymer, wherein the liposome comprises a lipid or phospholipid, wherein lipid or the phospholipid is selected from the group consisting of phosphatidylcholine (lecithin), lysolecithin, lysophosphatidylethanol-amine, phosphatidylserine, phosphatidylinositol, sphingomyelin, phosphatidylethanolamine (cephalin), cardiolipin, phosphatidic acid, cerebrosides, dicetylphosphate, phosphatidylcholine, and dipalmitoyl-phosphatidylglycerol, stearylamine, dodecylamine, hexadecyl-amine, acetyl palmitate, glycerol ricinoleate, hexadecyl stearate, isopropyl myristate, amphoteric acrylic polymers, fatty acid, fatty acid amides, cholesterol, cholesterol ester, diacylglycerol, and diacylglycerolsuccinate and wherein the biodegradable polymer is selected from the group consisting of polyesters, polylactides, polyglycolides, polycaprolactones, polyanhydrides, polyamides, polyurethanes, polyesteramides, polydioxanones, polyacetals, polyketals, polycarbonates, polyorthocarbonates, polyorthoesters, polyphosphoesters, polyphosphazenes, polyhydroxybutyrates, polyhydroxyvalerates, polyalkylene oxalates, polyalkylene succinates, poly(malic acid), poly(amino acids), copolymers, terpolymers, and combinations or mixtures thereof.
A method of ameliorating symptoms or treating one or more proliferative disorders, neurological disorders, neurodegenerative conditions, or any combinations thereof in a subject comprising the steps of:
- identifying the subject in need of amelioration of symptoms or treatment of the one or more proliferative disorders, neurological disorders, neurodegenerative conditions, or any combinations thereof;
- and
- administering intravenously one or more pharmaceutical compositions comprising a therapeutically effective amount of curcumin, synthetic curcumin (S-curcumin), curcumin analogues, curcumin derivatives or combinations thereof dissolved or dispersed in a suitable aqueous or non-aqueous medium, wherein the curcumin or the S-curcumin is enclosed in one or more spherical liposomes or is conjugated to one or more biodegradable polymers.
Dependencies are inferred from the claim text.