Topical liposomal compositions for delivering hydrophobic drugs and methods preparing same

A method for preparing a topical liposomal composition comprising:

• dissolving lipid components in a solvent;
• mixing the dissolved lipid components in said solvent with a plurality of additives selected from the group consisting of a penetration enhancer, an antimicrobial preservative, an antioxidant, and combinations thereof, forming a lipid phase thereof:
• melting said lipid phase, forming a uniform dissolved lipid phase;
• dissolving and mixing at least one hydrophobic drug into the solvent in the uniform lipid phase, forming an admixture thereof;
• heating said admixture;
• dissolving an emulsifier into a solution, preparing an aqueous phase thereof;
• heating said solution in said aqueous phase;
• and
• mixing and homogenizing the admixture and said solution in said aqueous phase to obtain said topical liposomal composition.