Back to results
US 2015/0147358 A1Published application
Methods for modulating immune responses
AssigneeStemnion, Inc.
InventorsRichard A. Banas, Catherine J. Trumpower, Vivienne S. Marshall
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeStemnion, Inc.
InventorsRichard A. Banas, Catherine J. Trumpower, Vivienne S. Marshall
Estimating the term…
The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents.
-18. (canceled)
A method for down-regulating the immune response a transplanted allogeneic graft tissue exhibits when it is exposed to host tissue in a subject receiving the transplant, the method comprising the step of simultaneously transplanting the graft tissue and a purified population of CD117-negative Amnion-derived Multipotent Progenitor (AMP) cells into the subject such that the AMP cells down-regulate the immune response exhibited by the graft tissue when it is exposed to host tissue.
A method for improving engraftment of an allogeneic graft tissue transplanted into a subject in need thereof, the method comprising the step of simultaneously transplanting the graft tissue and a purified population of CD117-negative Amnion-derived Multipotent Progenitor (AMP) cells into the subject such that the AMP cells down-regulate a graft-versus-host response following transplant such that improved engraftment of the allogeneic graft tissue results.
Dependencies are inferred from the claim text.