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US 2015/0147342 A1Published application
Methods for Treating Cancer by Administering an Anti-Ang-2 Antibody
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsIsrael Lowy, Gavin Thurston, Christopher Daly
Life of this patent
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Abstract
The present invention provides antibodies that bind to angiopoietin-2 (Ang-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human Ang-2. The antibodies of the invention are useful, inter alia, for the treatment of diseases and disorders associated with one or more Ang-2 biological activities including angiogenesis.
Claims11
1-29. (canceled)
A method for treating advanced hepatocellular cancer, the method comprising:
- (a) selecting a patient with advanced hepatocellular carcinoma wherein the patient is resistant to conventional anti-tumor therapy;
- and
- (b) sequentially administering to the patient in need thereof one or more doses of an antibody or antigen-binding fragment thereof which specifically binds human angiopoietin-2 (hAng-2) but does not substantially bind hAng-1, wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region (HCVR) comprising three heavy chain CDRs (HCDR1, HCDR2 and HCDR3) from SEQ ID NO:
- 18, and a light chain variable region (LCVR) comprising three light chain CDRs (LCDR1, LCDR2 and LCDR3) from SEQ ID NO:
- 20.
2 more elements
Dependencies are inferred from the claim text.