Dual Variable Domain Immunoglobulin and Uses Thereof
AssigneeAbbVie Inc.
InventorsChengbin WU, Tariq GHAYUR, Richard W. DIXON, Jochen G. SALFELD
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Abstract
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
Claims61
1-75. (canceled)
A multispecific binding protein comprising functional antigen binding sites for tumor necrosis factor (TNF) and interleukin 17 (IL-17).
A multispecific binding protein comprising functional antigen binding sites for interleukin 1 alpha (IL-1A) and interleukin 1 beta (IL-1B).
A multispecific binding protein comprising functional antigen binding sites for interleukin 1 beta (IL-1B) and interleukin 17 (IL-17).
A multispecific binding protein comprising functional antigen binding sites for a first target and a second target, wherein the first and/or second target is interleukin 17 (IL-17), tumor necrosis factor (TNF), interleukin 1 alpha (IL-1A), or interleukin 1 beta (IL-1B).
Dependencies are inferred from the claim text.