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US 2015/0147320 A1Published application
Ophthalmic Drug Delivery System Containing Phospholipid and Cholesterol
AssigneesTaiwan Liposome Co., Ltd., Tlc Biopharmaceuticals, Inc.
InventorsSHEUE-FANG SHIH, PO-CHUN CHANG, YUN-LONG TSENG, LUKE S.S. GUO, KEELUNG HONG
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Abstract
An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes.
Claims20
A drug delivery system, comprising
- (a) a delivery vehicle containing cholesterol and a phospholipid or a mixture of a first phospholipid and a second phospholipid, wherein the first phospholipid is DOPC, POPC, SPC, or EPC and the second phospholipid is PEG-DSPE or DOPG, and the cholesterol is present in an amount of 5-40 mole percent relative to the delivery vehicle;
- and
- (b) one or more therapeutic agent,
- wherein 50-90% of the therapeutic agent is in non-associated form and the weight ratio of the phospholipid and cholesterol in combination to the therapeutic agent is 5-80 to 1.
1 more element
Dependencies are inferred from the claim text.