Antibodies against hgf - receptor and uses

An antibody that specifically binds to the extracellular domain of the human HGF receptor (MET) (SEQ ID No:

• 1), wherein the antibody comprises:
• a heavy chain CDR1 comprising the amino acid sequence DYYMH (SEQ ID NO:2), or a variant thereof comprising 1, 2 or 3 amino acid substitutions,
• a heavy chain CDR2 comprising the amino acid sequence LVDPEDGETIYAEKFQ (SEQ ID NO:3), or a variant thereof comprising 1, 2 or 3 amino acid substitutions,
• a heavy chain CDR3 comprising the amino acid sequence DATTPYYGMDV (SEQ ID NO:4), or a variant thereof wherein
• the Y at position 7 is replaced with W,
• the G at position 8 is replaced with F,
• the M at position 9 is replaced with P,
• the D at position 10 is replaced with M, W, V, Q, R or Y, and/or
• the V at position 11 is replaced with E, W, Q, S, T, L, E or L, or a combination thereof,
• a light chain CDR1 comprising the amino acid sequence QASQDISNYLN (SEQ ID NO:13), or a variant thereof comprising 1, 2 or 3 amino acid substitutions,
• a light chain CDR2 comprising the amino acid sequence DASNLET (SEQ ID NO:14), or a variant thereof comprising 1, 2 or 3 amino acid substitutions, and
• a light chain CDR3 comprising the amino acid sequence QQGDSFPLT (SEQ ID NO:15), or a variant thereof comprising 1, 2 or 3 amino acid substitutions.