System and method for registering an image sequence

A method for registering an image sequence, comprising:

• obtaining the image sequence, the image sequence comprising a plurality of images arranged sequentially within an image range;
• establishing transformations between adjacent pairs of consecutive images in the image sequence to obtain a plurality of transformations as transformation matrices;
• based on the plurality of transformations, aligning the image sequence to a reference image to obtain a registered image sequence;
• wherein the method further comprises:
• establishing the reference image from the plurality of images based on a transformation metric, the transformation metric quantifying a degree of transformation required for aligning the image sequence to the reference image;
• and
• quantifying the degree of transformation in accordance with the transformation metric based on multiplication of the transformation matrices of the adjacent pairs of consecutive images. cm 16. A computer program product comprising instructions for causing a processor system to perform the method according to claim 15.