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AssigneeSnu R&Db Foundation
InventorsSeung Hyun Han, Ok-Jin Park, Cheol-Heul Yun
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The present invention relates to a bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide, an analogue thereof, a derivative thereof or a pharmaceutically acceptable salt thereof. In contrast to existing passive therapeutic agents which center on bone absorption suppression based on mechanisms for reducing osteoclast functionality, the composition comprising muramyl dipeptide of the present invention promotes the differentiation of osteoblasts, which are bone forming cells, and can advantageously be used in various diseases where bone formation is required as an active therapeutic agent that does not affect osteoclast.
A pharmaceutical composition for preventing bone loss or promoting bone regeneration or bone formation, which comprises a muramyl-dipeptide, an analog thereof, a derivative thereof or a pharmaceutically acceptable salt thereof.
A method for preventing bone loss or promoting bone regeneration or bone formation in a mammal in need thereof, the method comprising a administering to the mammal an effective amount of a muramyl-dipeptide or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.