US 2015/0132328 A1 · IMMUNOMODULATOR METALLOPEPTIDES (IMMPS) AND COMPOSITIONS CONTAINING SAME

Immunomodulator metallopeptides (immps) and compositions containing same

AssigneeUniversidad Autonoma Del Estado De Morelos

InventorsJorge Alberto Reyes Esparza, Maria de Lourdes Rodriguez Fragoso, Ana Laura Badillo Jimenez, Lorena Julieta Torres Aguilar, Lorenzo Ulises Martinez Osuna, Abril Arianna Martinez De Los Rios Corsino, Carlos Antonio Arjona Canul, Hugo Morales Rojas

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Abstract

The present invention relates to the field of human and veterinary medicine. The invention solves the problem associated with the lack of an agent for improving the immune response in immunosuppressed individuals, or with autoimmunity problems as well as infections; reducing the effects of the stress, combating tissue fibrosis; the need for anti-inflammatory agents; treatments for acute and chronic hepatitis, treatments against malignant processes and metastasis, as well as thrombocytopenia, both in humans and animals. The present invention comprises a molecular complex formed by a metallic ion and a peptide as novel compound, which is denominated as an immunomodulator metallopeptide hereafter abbreviated as IMMP. Claims also include the process for obtaining the complex, the use of the metallopeptide for producing a therapeutic or nutraceutic agent, and the use of that agent in humans and animals.

Claims29

Dependent claims

A immunomodulator metallopeptide, characterized in that comprises:

a) A peptide of formula:
Xn-Asp-Gly-Pro-Lys-Phe-Leu-Xm,
Where:
Xn and Xm are any independent aminoacid one from another,
n has a value of 0 to 4,
m has a value of 0 to 2, and
b) a divalent ion selecting from the group comprising:
Zn2+, Cu2+, Mg2+ o or mixtures thereof, wherein the peptide and the divalent ion are joined between each other by a non-covalent linking.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/348,326Filed 4 Oct 2011

Priority

MX MX/A/2011/01019028 Sep 2011

Published

14 May 2015

Term ends

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Classification8 codes

C07K 19/00
Hybrid peptides , i.e. peptides covalently bound to nucleic acids, or non-covalently
A61P 37/04
Immunomodulators: immunostimulants
C07K 7/06
Linear peptides containing only normal peptide links: having 5 to 11 amino acids
C07K 7/065
Having 5 to 11 amino acids: thymic humoral factor