Interfering rna molecules

A ribonucleic acid comprising a double stranded structure whereby the double-stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and whereby said first stretch is at least partially complementary to a target nucleic acid, and the second strand comprises a second stretch of contiguous nucleotides and whereby said second stretch is at least partially identical to a target nucleic acid, whereby the double stranded structure is blunt ended or has an overhang and a plurality of the ribonucleic acids on the first or second stretch/strand has a modification at the 2′-position and the modification is selected from an amino, fluoro, methoxy, alkoxy or alkyl modification.

The ribonucleic acid according to claim wherein at least one of the strands has an overhang of at least one nucleotide at the 3′-end consisting of ribonucleotide or deoxyribonucleotide.