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US 2015/0105540 A1Published application
Drug-conjugates with a targeting molecule and two different drugs
AssigneeSorrento Therapeutics, Inc.
InventorsZhenwei Miao, Gang Chen, Tong Zhu, Alisher B. Khasanov, Yufeng Hong, Hong D. Zhang, Alexander Chucholowski
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Abstract
There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.
Claims15
A dual-drug conjugate comprising a structure of Formula I
- or a pharmaceutically acceptable salt thereof,
- wherein:
- A is a targeting protein;
- each D1 may be independently selected, where each D1 includes an active agent;
- each L1 is independently a linker including at least one N (nitrogen) atom;
- each D2 is independently selected, where each D2 includes an active agent;
- each L2 is independently a linker;
- the E-component is an optionally substituted heteroaryl or an optionally substituted heterocyclyl;
- each L3 is an optionally substituted C1-C6 alkyl, or each L3 is null, when L3 is null the sulfur is directly connected to the E-component;
- and
- each L4 is an optionally substituted C1-C6 alkyl, or each L4 is null, when L4 is null the sulfur is directly connected to the E-component;
- m is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;
- and
- n is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
11 more elements
Dependencies are inferred from the claim text.