Pharmaceutical composition comprising a trpa1 antagonist and an analgesic agent
AssigneeGlenmark Pharmaceuticals S.A.
InventorsSrinivas GULLAPALLI, Praveen Kumar GUPTA, Maulik Nitinkumar GANDHI, Sravan MANDADI
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Abstract
The present patent application relates to a pharmaceutical composition comprising a TRPA1 antagonist and an analgesic agent. Particularly, the present patent application provides a pharmaceutical composition comprising a thienopyrimidinedione compound as a TRPA1 antagonist and an analgesic agent; and use of such composition for treating pain in a subject.
Claims24
A pharmaceutical composition comprising
- (i) a transient receptor potential ankyrin-1 (“TRPA1”) antagonist compound selected from a group consisting of N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide;
- 4-(2,4-difluoro-3-(trifluoromethyl)phenyl)-2-((2-(2,5,7-trimethyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl)acetyl)imino)thiazol-3(2H)-yl)methyl dihydrogen phosphate;
- and a pharmaceutically acceptable salt thereof, and
- (ii) an analgesic agent, wherein the TRPA1 antagonist and the analgesic agent are present in a weight ratio ranging from about 1:0.001 to about 1:800.
A pharmaceutical composition comprising
- (i) a therapeutically effective amount of Compound I or its pharmaceutically acceptable salt;
- and
- (ii) an analgesic agent selected from duloxetine, pregabalin, gabapentin and a salt thereof, wherein the weight ratio of the Compound I or its pharmaceutically acceptable salt to the analgesic agent ranges from about 1:0.001 to about 1:500.
A method of enhancing analgesic activity of an analgesic agent in a subject in need thereof comprising administering to the subject said analgesic agent in combination with N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide or a salt thereof.
Dependencies are inferred from the claim text.