Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors

A compound of Formula (I):

• or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
• R1 is independently selected from the group consisting of:
• H, —((CH2)sO)r(C1-4 alkyl substituted with 0-1 Ra), C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra, —SO2(phenyl), —(CH2)n—(C3-6 cycloalkyl substituted with 0-3 Rc), —(CH2)n(CHRf)(CH2)m-phenyl, —(CH2)n-(phenyl substituted with 0-3 Rb), and —(CH2)n-(5- to 6-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S(O)p);
• and wherein said heterocycle is substituted with 0-3 Rc;
• R2 is independently selected from the group consisting of:
• OR6, CN, and NR7R8;
• R3 is independently selected from the group consisting of:
• H, halogen, CF3, OCF3, C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra, —CO2(C1-4 alkyl), —SO2(phenyl), —(CH2)n—(C3-6 cycloalkyl substituted with 0-3 Rc), —(CH2)n-(phenyl substituted with 0-3 Rb), —(CH2)n-(naphthyl substituted with 0-3 Rb), and —(CH2)n-(5- to 10 membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S(O)p), wherein said heterocycle is substituted with 0-3 Rc;
• R4 is independently selected from the group consisting of:
• H and C1-4 alkyl;
• R5 is independently selected from the group consisting of:
• C3-6 cycloalkyl, phenyl, naphthyl, and a 5- to 10-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S(O)p;
• and wherein each moiety is substituted with 0-3 Rd;
• R6 is C1-6 alkyl substituted with 0-1 CO2H;
• R7 is independently selected from the group consisting of:
• H, C1-6 alkyl substituted with 0-1 Ra, —(CH2)n-(phenyl substituted with 0-3 Rb), and —(CH2)n-(5- to 6-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S(O)p);
• and wherein said heterocycle is substituted with 0-3 Rc;
• R8 is independently selected from the group consisting of:
• H and C1-6 alkyl;
• alternatively, NR7R8 is a 5- to 6-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S(O)p;
• L is independently a hydrocarbon or hydrocarbon-heteroatom linker optionally substituted with 0-2 Rg;
• wherein said hydrocarbon linker has one to eight carbon atoms and may be straight or branched, saturated or unsaturated;
• and said hydrocarbon-heteroatom linker may be saturated or unsaturated and has one to seven carbon atoms and one group selected from O, —CO—, S, —SO—, —SO2—, NH, and N(C1-4 alkyl);
• Ra is, independently at each occurrence, selected from the group consisting of:
• halogen, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CF3, OCF3, CN, NH2, NO2, NH(C1-4 alkyl), N(C1-4 alkyl)2, CO2H, CO2(C1-4 alkyl), NHCO(C1-4 alkyl substituted with 0-1 NH2), N(C1-4 alkyl)CO(C1-4 alkyl), NHCO2(C1-4 alkyl), CONHSO2(C1-4 alkyl), SO2(C1-4 alkyl), CONH2, CONH(C1-4 alkyl), NHSO2(C1-4 alkyl), N(C1-4 alkyl)SO2(C1-4 alkyl), and phenoxy;
• Rb is, independently at each occurrence, selected from the group consisting of:
• halogen, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CF3, OCF3, OCF2CHF2, OCH2CF3, CN, NH2, NO2, NH(C1-4 alkyl), N(C1-4 alkyl)2, CO2H, CO2(C1-4 alkyl), CONH2, CONH(C1-4 alkyl), CON(C1-4 alkyl)2, NHCO2(C1-4 alkyl), NHSO2(C1-4 alkyl), N(C1-4 alkyl)SO2(C1-4 alkyl), SO2(C1-4 alkyl), SO2NH2, phenyl, benzyl, and phenoxy;
• Rc is, independently at each occurrence, selected from the group consisting of:
• ═O and Rb;
• Rd is, independently at each occurrence, selected from the group consisting of:
• halogen, OH, C1-6 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CF3, OCF3, CN, NH2, NO2, NH(C1-4 alkyl), N(C1-4 alkyl)2, CO2H, CO2(C1-4 alkyl), CONH2, CONH(C1-4 alkyl), CON(C1-4 alkyl)2, NHCO2(C1-4 alkyl), NHSO2(C1-4 alkyl), SO2(C1-4 alkyl), and SO2NH2;
• Re is, independently at each occurrence, selected from the group consisting of:
• H, C1-4 alkyl, CO(C1-4 alkyl), CO2(C1-4 alkyl), CO2(benzyl), and —(CH2)n-(phenyl optionally substituted with 0-2 halogens);
• Rf is, independently at each occurrence, selected from the group consisting of:
• C1-4 alkyl, C2-4 alkenyl, CO2(C1-4 alkyl), CONH2, C3-6 cycloalkyl, phenyl, and benzyl;
• Rg is, independently at each occurrence, selected from the group consisting of:
• halogen, OH, C1-4 alkyl, C2-4 alkenyl, C1-4 haloalkyl, C1-4 alkyoxy, CO2(C1-4 alkyl), C3-6 cycloalkyl, and phenyl;
• m, at each occurrence, is selected from 0, 1, and 2;
• n, at each occurrence, is selected from 0, 1, 2, 3, and 4;
• p, at each occurrence, is selected from 0, 1, and 2;
• and
• s and r are, independently at each occurrence, selected from 1, 2, 3, and 4.