High-purity cyclopeptide crystal as well as preparation method and use thereof

A cyclopeptide comprising one or more compounds selected from the group consisting of:

• crystal A of cyclopeptide of formula I, wherein R represents H or a cation capable of forming a pharmaceutically acceptable salt, and X-ray powder diffraction pattern (XRPD) of said crystal A shows characteristic peaks at the following 2θ angles:
• 7.1±0.2, 8.0±0.2, 14.7±0.2, 16.8±0.2, 18.9±0.2, 20.3±0.2, 21.1±0.2;
• crystal B of cyclopeptide of formula I, wherein R represents H or a cation capable of forming a pharmaceutically acceptable salt, and X-ray powder diffraction pattern (XRPD) of said crystal B shows characteristic peaks at the following 2θ angles:
• 7.3±0.2°, 11.9±0.2°, 12.8±0.2°, 16.8±0.2°, 19.6±0.2°, 21.1±0.2°, 22.1±0.2°, 22.8±0.2°, 24.3±0.2°, 25.4±0.2°;
• crystal C of cyclopeptide of formula I, wherein R represents H or a cation capable of forming a pharmaceutically acceptable salt, and X-ray powder diffraction pattern (XRPD) of said crystal C shows characteristic peaks at the following 2θ angles:
• 8.6±0.2°, 11.9±0.2°;
• crystal D of cyclopeptide of formula I, wherein R represents H or a cation capable of forming a pharmaceutically acceptable salt, and X-ray powder diffraction pattern (XRPD) of said crystal D shows characteristic peaks at the following 2θ angles:
• 5.6±0.2°, 14.4±0.2°, 19.8±0.2°, 22.7±0.2°, 23.0±0.2°, 23.9±0.2°;
• crystal E of cyclopeptide of formula I, wherein R represents H or a cation capable of forming a pharmaceutically acceptable salt, and X-ray powder diffraction pattern (XRPD) of said crystal E shows characteristic peaks at the following 2θ angles:
• 9.7±0.2°, 19.8±0.2°, 23.0±0.2°;
• crystal F of cyclopeptide of formula I, wherein R represents H or a cation capable of forming a pharmaceutically acceptable salt, and X-ray powder diffraction pattern (XRPD) of said crystal F shows characteristic peaks at the following 2θ angles:
• 7.0±0.2°, 7.9±0.2°, 12.6±0.2°, 14.1±0.2°, 18.5±0.2°, 20.6±0.2°, 21.6±0.2°, 35.6±0.2°;
• crystal G of cyclopeptide of formula I, wherein R represents H or a cation capable of forming a pharmaceutically acceptable salt, and X-ray powder diffraction pattern (XRPD) of said crystal G shows characteristic peaks at the following 2θ angles:
• 7.3±0.2°, 19.8±0.2°, 21.1±0.2°.