Methods and Pharmaceutical Compositions for Prevention or Treatment of Ischemia Related Organ Damage
AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), Universite de Sherbrooke, Universite Paris Descartes, Universite Pierre et Marie Curie (Paris IV), Assistance Publique-Hopitaux de Paris, Universite Paris Vii (Denis Diderot)
InventorsFrancois Alhenc-Gelas, Nadine Bouby, Fernand Junior Gobeil, Ronan Roussel, Ludovic Waeckel, Louis Potier
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Abstract
The present invention relates to methods and compositions for the prevention or treatment of ischemia related organ damage.
Claims11
A method of preventing or treating ischemia related organ damage in a subject in need thereof, comprising,
- administering to said subject a therapeutically effective amount of a B2-receptor agonist.
A pharmaceutical composition for use in the prevention and treatment of ischemia related organ damage in a subject in need thereof comprising a B2-receptor agonist and a pharmaceutical acceptable carrier.
A method of screening a candidate compound for use as a drug for the prevention or treatment of ischemia related organ damage in a subject in need thereof, wherein the method comprises the steps of:
- providing a B2-receptor, providing a cell, tissue sample or organism expressing a B2-receptor,
- providing a candidate compound selected from the group consisting of small organic molecules, peptides, polypeptides, peptide mimetics, metabolically and/or conformationally stabilized peptide analogs, derivatives or pseudo-peptides,
- measuring the B2-receptor activity,
- and selecting positively candidate compounds that induce B2-receptor activity.
Dependencies are inferred from the claim text.