Porphyrin-Lipid Stabilized Nanoparticles for Surface Enhanced Raman Scattering Based Imaging
AssigneeUniversity Health Network
InventorsGang Zheng, Natalie Tam
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Abstract
Herein are provided nano-particles comprising a nanocore of Raman-scattering material stabilized by a bilayer comprising a porphyrin-phospholipid conjugate, methods of making the same and their use in Surface Enhanced Raman Scattering.
Claims28
A nanoparticle comprising a nanocore, the nanocore comprising Raman-scattering suitable material, surrounded by a bilayer comprising porphyrin-phospholipid conjugate, wherein each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid.
A method of preparing nanoparticles, comprising:
- a. preparing a solution comprising porphyrin-phospholipid conjugate, wherein the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain of one phospholipid, preferably at the sn-1 or the sn-2 position;
- the solution optionally further comprising other phospholipid;
- b. dehydrating the solution to provide a lipid film;
- and
- c. rehydrating the lipid film along with a nanocore comprising Raman-scattering suitable material;
- and optionally voertexing, sonicating or centrifuging the resulting solution.
-29. (canceled)
Dependencies are inferred from the claim text.