Substituted imidazopyridazines

A compound of general formula I:

• in which:
• A represents
• wherein * indicates the point of attachment of said group with the rest of the molecule;
• R2 represents a methyl-, ethyl- or cyclopropyl- group;
• wherein said methyl- or ethyl- group is optionally substituted, identically or differently, with 1, 2, 3 or 4 groups selected from:
• halogen, —OH, —CN, C1-C3-alkoxy-;
• wherein said cyclopropyl- group is optionally substituted, identically or differently, with 1, 2, 3 or 4 groups selected from:
• halogen, —OH, —CN, C1-C3 alkyl-, C1-C3 alkoxy-, HO—C1-C3 alkyl-, halo C1-C3 alkyl-;
• R3 represents
• —C(R3a)(R3b)(R3c);
• R3a, R3b
• represent, independently from each other, a hydrogen atom or a halogen atom or a hydroxy-, C1-C3-alkyl-, HO—C1-C3-alkyl-, C2-C4-alkenyl-, halo-C1-C3-alkyl-, C1-C3-alkoxy- or halo-C1-C3-alkoxy- group, with the proviso that not both of R3a and R3b represent a hydrogen atom and not both of R3a and R3b represent a hydroxy group;
• or
• R3a, R3b
• together represent ═O or ═C(R3d)(R3e);
• or
• R3a, R3b
• together with the carbon atom they are attached to, form a cyclopropyl- or cyclobutyl-ring;
• wherein said cyclopropyl- or cyclobutyl-ring is optionally substituted, identically or differently, with 1 or 2 R3d groups;
• or
• R3 represents
• wherein * indicates the point of attachment of said group with the rest of the molecule;
• R3c represents an aryl- or heteroaryl- group;
• wherein said aryl- or heteroaryl- group is substituted, identically or differently, with 1, 2, 3 or 4 R7 groups;
• R3d, R3e
• represent, independently from each other, a hydrogen atom or a C1-C3-alkyl- group;
• R4 represents a hydrogen atom, a halogen atom, or a —CN, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl- or halo-C1-C3-alkoxy- group;
• R5 represents a hydrogen atom or a C1-C6-alkyl-, —(CH2)n—C2-C6-alkenyl, —(CH2)n—C2-C6-alkynyl, —(CH2)m—C3-C6-cycloalkyl, —(CH2)m-(3- to 7-membered heterocycloalkyl), aryl C1-C6-alkyl-, heteroaryl-C1-C6-alkyl-, halo-C1-C6-alkyl-, R6a(R6b)N—C1-C6-alkyl-, HO—C1-C6-alkyl-, —C1-C6-alkyl-CN, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, C3-C6-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, C4-C8-cycloalkenyl-, aryl- or heteroaryl- group;
• wherein said C1-C6-alkyl-, —(CH2)n—C2-C6-alkenyl, —(CH2)n—C2-C6-alkynyl, —(CH2)m—C3-C6-cycloalkyl, —(CH2)m-(3- to 7-membered heterocycloalkyl), aryl-C1-C6-alkyl-, heteroaryl-C1-C6-alkyl-, —C1-C6-alkyl-, R6a(R6b)N—C1-C6-alkyl-, HO—C1-C6-alkyl, —C1-C6-alkyl-CN, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, C3-C6-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, C4-C8-cycloalkenyl-, aryl- or heteroaryl- group is optionally substituted, identically or differently, with 1, 2, 3, 4 or 5 R8 groups;
• R6, R6a, R6b
• represent, independently from each other, a hydrogen atom or a C1-C6-alkyl- group;
• R7 represents a halogen atom, or a hydroxy-, —CN, C1-C6-alkoxy-, C1-C6-alkyl-, halo-C1-C6-alkyl-, R6a(R6b)N—C1-C6-alkyl-, HO—C1-C6-alkyl-, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl- group;
• R8 represents a hydrogen or halogen atom or a —CN, C1-C6-alkoxy-, C1-C6-alkyl-, halo-C1-C6 alkyl-, R6a(R6b)N—C1-C6-alkyl-, HO—C1-C6-alkyl-, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, —C(═O)R6, —C(═O)N(H)R6a, —C(═O)N(R6a)R6b, —C(═O)O—R6, —N(R6a)R6b, —NO2, —N(H)C(═O)R6, —N(R6c)C(═O)R6, —N(H)C(═O)N(R6a)R6b, —N(R6c)C(═O)N(R6a)R6b, —N(H)C(═O)OR6, —N(R6c)C(═O)OR6, —N(H)S(═O)R6, —N(R6c)S(═O)R6, —N(H)S(═O)2R6, —N(R6c)S(═O)2R6, —N═S(═O)(R6a)R6b, —OR6, —O(C═O)R6, —O(C═O)N(R6a)R6b, —O(C═O)OR6, —SR6, S(═O)R6, —S(═O)N(H)R6, —S(═O)N(R6a)R6b, —S(═O2)R6, —S(═O)2N(H)R6, —S(═O)2N(R6a)R6b, —S(═O)(═NR6c)R6 or —S(═O)2-(3- to 7-membered heterocycloalkyl) group;
• wherein said 3- to 7-membered heterocycloalkyl- or heteroaryl- group is optionally substituted, identically or differently, with 1, 2, 3 or 4 C1-C6-alkyl- groups;
• m is an integer of 0, 1 or 2;
• n is an integer of 0, 1 or 2;
• or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.