Compositions and kits for the removal of irritating compounds from bodily surfaces
AssigneeAcorda Therapeutics, Inc.
InventorsArturo J. ANGEL, Larry W. LITLE, Keith R. BLEY, Allan L. WILCOX, Gene C. JAMIESON, Naweed MUHAMMAD
Life of this patent
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Abstract
The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.
Claims24
A kit, comprising:
- a) a first composition comprising capsaicin or a capsaicin analog;
- and
- b) a second composition comprising a substance in which the capsaicin or capsaicin analog is soluble.
A kit, comprising:
- a) a first composition comprising a patch comprising capsaicin or capsaicin analog at an amount of about 0.64 mg/cm2;
- b) a second composition comprising a cleansing gel comprising:
- i) about 84 to about 94 percent w/w polyethylene glycol;
- ii) about 0.1 to about 2.0 percent w/w polyacrylate thickening agent;
- and
- iii) about 0.005 to about 0.05 percent w/w butylated hydroxyanisole;
- iv) about 0.05 to about 0.5 percent w/w edetate sodium;
- and
- v) the balance water;
- wherein the second composition is at a pH of about 7.0 to 7.7.
A composition for cleansing a bodily surface comprising:
- a) about 60 to about 99 percent w/w polyethylene glycol (PEG);
- b) about 0.1 to about 4.0 percent w/w polyacrylate thickening agent;
- and
- c) the balance water;
- wherein the composition is at a pH between about 6.0 and about 8.0.
A method for treating pain in an individual in an area of the body affected by pain, comprising:
- a) administering an afferent nerve fiber blocking regional anesthetic to the affected area;
- b) affixing to the affected area a device, wherein said device comprises a skin-adherent patch, the patch including a reservoir comprising a therapeutic formulation whereby said formulation is continuously provided to the surface of the skin for a predetermined period of time, wherein said formulation comprises capsaicin or a capsaicin analog in a total concentration from greater than about 5% to 10% by weight of the formulation, wherein a single administration of said patch affords significant relief of said pain to said individual for at least several weeks;
- and
- c) cleansing the area to which the patch of step b) has been applied by
- i) applying to the area a composition comprising about 80 to about 99 percent w/w polyethylene glycol;
- about 0.1 to about 2.0 percent w/w polyacrylate thickening agent;
- and the balance water;
- wherein the composition is at a pH of about 7.0 to about 7.7;
- and
- ii) removing the composition of step (c) from the area.
A method for cleansing a bodily surface that has been contacted with an irritating or painful substance, comprising:
- a) applying to the bodily surface a composition comprising:
- i) about 80 to about 99 percent w/w polyethylene glycol;
- ii) about 0.1 to about 2.0 percent w/w polyacrylate thickening agent;
- and
- iii) the balance water;
- wherein the composition is at a pH of about 7.0 to about 7.7;
- and
- b) removing the composition of step (a) from the bodily surface.
Dependencies are inferred from the claim text.