Growth-inhibited hydroxyapatite, process for its preparation and use
AssigneeTechnische UniversitäT Dresden
InventorsSascha Heinemann, Christiane Heinemann, Hartmut Worch, Thomas Hanke, Wolfgang Pompe
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Abstract
A growth-inhibited hydroxyapatite is contained in agglomerates of prestructured collagen templates, wherein the prestructured collagen templates are denatured or broken up so that fibrillogenesis of the prestructured collagen templates is inhibited. Epitactic hydroxyapatite crystallites with a crystallite size below a critical nucleus radius are formed on the prestructured collagen templates.
Claims6
A growth-inhibited hydroxyapatite contained in agglomerates of prestructured collagen templates, wherein the prestructured collagen templates are denatured or broken up so that fibrillogenesis of the prestructured collagen templates is inhibited, and wherein epitactic hydroxyapatite crystallites with a crystallite size below a critical nucleus radius are formed on the prestructured collagen templates.
A growth-inhibited hydroxyapatite as an implant material or for coating implants, the growth-inhibited hydroxyapatite produced from prestructured collagen templates, denatured or broken up so that fibrillogenesis of the prestructured collagen templates is inhibited, wherein the prestructured collagen templates are capable of diffusion or migration, by mineralizing the prestructured collagen templates by incubating the prestructured collagen templates in supersaturated solutions containing Ca ions, wherein the Ca ions deposit in a predetermined way on the prestructured collagen templates, and by subsequently incubating the prestructured collagen templates in a phosphate-containing solution to grow epitactic hydroxyapatite crystallites on the prestructured collagen templates, wherein the Ca ions deposited in a predetermined way determine decisively growth inhibition of the hydroxyapatite crystallites, and by agglomerating the prestructured collagen templates with grown-on hydroxyapatite crystallites by diffusion or migration of the prestructured collagen templates, followed by separating the agglomerates.
Dependencies are inferred from the claim text.