A method of treatment of pain, inflammation, itching, angiogenic disorders and/or diseases of the skin and/or pigmentation disorders and/or diseases, inhibition of cytokine release, inhibition of matrix metalloproteinase activity or inhibition of melanogenesis, which comprises the administration to a mammal's body of a cosmetically or pharmaceutically effective quantity of at least one compound of general formula (I),
- R1—Wn—Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp—Zq—R2 (I)
- its stereoisomers, mixtures thereof and/or its cosmetically or pharmaceutically acceptable salts, wherein
- AA1 is selected from the group consisting of -Ser- and a bond;
- AA2 is selected from the group consisting of -Val- and -Ala -;
- AA3 is selected from the group consisting of -Arg- and -Thr-;
- AA4 is selected from the group consisting of -Val- and -Asn-;
- AA5 is selected from the group consisting of -Ala- and -Thr-;
- AA6 is selected from the group consisting of -Val- and a bond;
- W, X, Y, Z are amino acids and are independently selected from amongst themselves;
- n, m, p and q are independently selected from amongst themselves and have a value of 0 or 1;
- n+m+p+q is smaller than or equal to 2;
- with the condition that if AA1 is a bond, AA2 is -Val-, AA3 is -Thr-, AA4 is -Val-, AA5 is -Ala-, and AA6 is a bond, then p and q are 0;
- R1 is selected from the group consisting of H, a polymer derived from polyethylene glycol, substituted or unsubstituted non-cyclic aliphatic groups, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO—, wherein R5 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic groups, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl;
- R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3, wherein R3 and R4 are independently selected from the group consisting of H, a polymer derived from polyethylene glycol, substituted or unsubstituted non-cyclic aliphatic groups, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl;
- and
- R1 or R2 are not α-amino acids.