Compositions and methods for tissue repair
AssigneesTransTarget, Inc., The Regents of the University of California
InventorsRandall J. Lee, Shirley Mihardja, Manley Huang, James W. Larrick
Life of this patent
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Abstract
The present invention provides compositions and methods for targeting an extracellular matrix derived (EMD) peptide predominantly to an injured tissue, as opposed to an uninjured tissue in vivo. The targeted EMD peptide facilitates the repair and/or regeneration of the injured tissue by providing a surface for cells to attach and grow, thereby facilitating the repair and/or regeneration of the injured tissue.
Claims26
A composition for repair of an injured tissue, the composition comprising an injury-associated antigen-specific binding component conjugated to an extracellular matrix derived (EMD) peptide,
- wherein the injury-associated antigen-specific binding component comprising a molecule that specifically binds an antigen expressed following tissue injury, and
- wherein the EMD peptide is a peptide or a concatamer of a peptide that ranges in length from about 8 amino acid residues to about 100 amino acid residues, and exhibits the ability to:
- (i) activate cells;
- (ii) attach cells;
- and (iii) exhibits a chemotropic property.
A method for repairing an injured tissue, the method comprising administering to a mammalian subject a composition having an injury-associated antigen-specific binding component conjugated to an extracellular matrix derived (EMD) peptide,
- wherein the injury-associated antigen-specific binding component comprising a molecule that specifically binds an antigen expressed following tissue injury, and
- wherein the EMD peptide is a peptide or a concatamer of a peptide that ranges in length from about 8 amino acid residues to about 100 amino acid residues, and exhibits the ability to:
- (i) activate cells;
- (ii) attach cells;
- and (iii) exhibits a chemotropic property and
- wherein said composition is administered in an amount sufficient to facilitate repair or regeneration of the injured tissue.
Dependencies are inferred from the claim text.