Use of Semaphorin-4D Binding Molecules for Treatment of Atherosclerosis
AssigneeVaccinex, Inc.
InventorMaurice Zauderer
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Abstract
Provided herein are methods for reducing, inhibiting, suppressing and/or delaying atherosclerotic plaque growth or neovascularization in a subject having atherosclerosis, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to Semaphorin-4D (SEMA4D) or to its high affinity Plexin-B1 receptor.
Claims24
A method for inhibiting, suppressing, reducing or delaying growth of atherosclerotic plaques in a subject having atherosclerosis, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to Semaphorin-4D (SEMA4D).
A method for inhibiting, delaying, reducing or delaying neovascularization in a subject having atherosclerosis, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to Semaphorin-4D (SEMA4D).
A method for treating a subject having atherosclerosis, comprising:
- administering to a subject determined to have atherosclerotic plaques an effective amount of an isolated binding molecule which specifically binds to Semaphorin-4D (SEMA4D), thereby inhibiting, delaying, reducing or delaying growth of atherosclerotic plaques.
Dependencies are inferred from the claim text.