Cardiac muscle repair or regeneration using bone marrow-derived stem cells
AssigneeMesoblast International Sarl
InventorsMark F. Pittenger, Stephen L. Gordon, Alastair Morgan Mackay
Life of this patent
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Abstract
Disclosed are compositions and methods for repairing and/or regenerating cardiac tissue by administering adult bone marrow-derived stem cells to an individual. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation.
Claims23
A cell preparation comprising adult bone marrow-derived stem cells in a dose effective to augment ventricular function in the heart of a subject in need thereof.
A method of improving left ventricular ejection fraction in a patient comprising the step of:
- administering to the patient adult bone marrow-derived stem cells in an amount effective to improve ventricular ejection fraction.
A method of treating a patient having myocardial infarction or congestive heart failure and having reduced cardiac function comprising the step of:
- administering to the patient adult bone marrow-derived stem cells in an amount effective to improve cardiac function.
A method of augmenting ventricular function in a patient comprising the step of:
- administering to the heart of the patient a cell suspension, wherein the cell suspension comprises adult bone marrow-derived stem cells and a pharmaceutically acceptable liquid medium.
Dependencies are inferred from the claim text.