Compositions and Treatment Methods for Mesenchymal Stem Cell-Induced Immunoregulation
AssigneeUniversity of Southern California
InventorsSongtao Shi, Kentaro Akiyama, Chider Chen
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Abstract
Mesenchymal Stem Cells (MSCs), including bone marrow-derived MSCs (BMMSCs) expressing Fas and FasL, and secreting MCP-1 are disclosed. Also disclosed are methods for upregulating regulatory T cells in a subject by administering MSCs, including BMMSCs. Also disclosed are methods for treating systemic sclerosis or colitis in a subject by administering MSCs, including BMMSCs.
Claims22
A method of treating a patient comprising administering a composition comprising a therapeutically effective amount of an isolated and purified population of mesenchymal stem cells (MSCs) to the patient, wherein said MSCs:
- a) express Fas, b) express FasL and c) secrete MCP-1.
(canceled)
10-22. (canceled)
An isolated and purified population of MSCs, wherein said MSCs a) express Fas, b) express FasL and c) secrete MCP-1.
28-43. (canceled)
Dependencies are inferred from the claim text.