Radiolabelled glutaminyl cyclase (qc) inhibitors and uses of same
AssigneeProbiodrug AG
InventorsUlrich Heiser, Daniel Ramsbeck, Hans-Ulrich Demuth
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Abstract
Radiolabeled glutaminylcyclase (QC) inhibitors as imaging agents, in particular, but not exclusively, as medical imaging agents for the detection of neurological disorders; and pharmaceutical compositions, methods and kits for detecting neurological disorders, using the radiolabeled inhibitors.
Claims19
A radiolabeled glutaminylcyclase (QC) inhibitor, wherein:
- the radiolabel is selected from the group consisting of 2H (D or deuterium), 3H (T or tritium), 11C, 13C, 14C, 13N, 15N, 15O, 17O, 18O, 18F, 35S, 36Cl, 82Br, 75Br, 76Br, 77Br, 123I, 124I, 125I, and 131I;
- and
- the radiolabeled QC inhibitor is suitable for use as an imaging agent.
The pharmaceutical composition of 13, wherein the neurological disorder is selected from the group consisting of mild cognitive impairment, Alzheimer's disease, Familial British Dementia, Familial Danish Dementia, neurodegeneration in Down Syndrome, and Huntington's disease.
Dependencies are inferred from the claim text.