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US 2015/0094648 A1Published application
Microneedle and microneedle array
AssigneesTeljin Limited, Medrx Co., Ltd.
InventorsKiyotsuna Toyohara, Taishi Tanaka, Kazuki Kohno, Takashi Oda, Koichi Masaoka, Katsunori Kobayashi, Masaki Ishibashi, Hidetoshi Hamamoto
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Abstract
The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently.
Claims12
A microneedle for administering a drug transdermally, which comprises a top section, a shaft section and a base section, wherein
- (i) the tip apex angle (α) is 15 to 60°;
- (ii) the tip diameter (D0) is 1 to 20 μm;
- (iii) the area (A3) of the top surface of the base section is larger than the area (A2) of the bottom surface of the shaft section;
- (iv) the following expressions (1) and (2) are satisfied;
- H/D4≧3 (1)
- (H is the overall height, and D4 is the diameter of the bottom surface of the base section.)
- β≧90−0.5α (2)
- (β is the angle between the side surface of the shaft section and the top surface of the base section, and α is the tip apex angle.);
- and
- (v) a solid composition containing the drug is fixed to the side surface of the shaft section and the following expression (5) is satisfied.
- 10°≦γ≦60° (5)
- (γ is the angle formed by tangent lines connecting the apex of the top section and the surface of the solid composition fixed to the side surface of the shaft section.)
9 more elements
Dependencies are inferred from the claim text.