Image-guided therapy of a tissue

A system for effecting treatment to a tissue, comprising:

• a motorless drive mechanism that is compatible with and can operate within an operational field of a medical imaging system to image the tissue without substantially disrupting imaging performed by the medical imaging system, the motorless drive mechanism including a holder to hold a treatment device to treat the tissue, and a first wire translation mechanism that couples one or more wires to the holder, such that a translation of the one or more wires effects one or more of a longitudinal displacement of the holder and a rotation of the holder;
• a base unit that is coupled to the motorless drive mechanism by the one or more wires, the base unit including a second wire translation mechanism to translate the one or more wires;
• and
• an electronic controller including an input interface to receive position control signals for setting a position of the treatment device, and an output interface that is coupled to the second wire translation mechanism of the base unit, such that the output interface effects movements of the second wire translation mechanism to translate the one or more wires based on the position control signals received by the input interface to effect movements of the first wire translation mechanism, such that one or more of the longitudinal displacement of the holder and the rotation of the holder are effected based on the position control signals received by the input interface.