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US 2015/0087603 A1Published application
Modified peptide toxins
AssigneesUniversity of Szeged, University of Debrecen
InventorsZoltan Varga, Gyorgy Panyi, Gabor Toth, Kinga Rakosi
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Abstract
The invention relates to toxin peptides capable of selectively inhibiting a Kv1.3 potassium channel protein. The toxin peptides of the invention are modified anuroctonus scorpion toxin peptides.
Claims11
A toxin peptide capable of selectively inhibiting a Kv1.3 potassium channel protein,
- said peptide having or consisting essentially of 32 to 36 amino acid residues, more preferably 33, 34 or 35 amino acid residues)
- said peptide having four disulphide bridges, wherein said peptide comprises the following amino acid sequence:
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- Z
- X1
- X2
- C1
- X3
- X4
- X5
- X6
- X7
- C2
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
- X8
- X9
- X10
- C3
- X11
- X12
- X13
- K1
- C4
- T1
- 21
- 22
- 23
- 24
- 25
- 26
- 27
- 28
- 29
- 30
- X14
- G1
- K2
- C5
- X15
- N1
- R1
- K3
- C6
- X16
- 31
- 32
- 33
- 34
- 35
- C7
- T1
- N2
- C8
- X17
- wherein
- Pos.
- 1
- Z is pyroglutamate, glutamate (E), aspartate (D), asparagine (N)
- or glutamine (Q),
- 2
- X1 is lysine (K) or arginine (R) or nothing,
- 3
- X2 is glutamate (E) or aspartate (D) or nothing
- 4
- C1 is cysteine
- 5
- X3 is threonine (T) or serine (S)
- 6
- X4 is glycine (G) or alanine (A)
- 7
- X5 is proline (P) or serine (S)
- 8
- X6 is glutamine (Q), asparagine (N), glutamate (E), aspartate (D)
- or lysine (K)
- 9
- X7 histidine (H), phenylalanine (F), aspartate (D) or glutamine (Q)
- 10
- C2 is cysteine
- 11
- X8 is threonine (T), serine (S), alanine (A), leucine (L) or
- isoleucine (I),
- 12
- X9 is asparagine (N), glutamate (E), glutamine (Q) or lysine (K),
- 13
- X10 is phenylalanine (F), proline (P) or histidine (H),
- 14
- C3 is cysteine
- 15
- X11 is lysine (K) or arginine (R),
- 16
- X12 is lysine (K) or aspartate (D) wherein preferably if
- X12 is lysine (K) then X13 is alanine (A)
- or asparagine (N), whereas if X12 is aspartate (D) then
- X13 is asparagine (N)
- 17
- X13 is alanine (A) or asparagine (N) wherein preferably if
- X12 is lysine (K) then X13 is alanine (A)
- or asparagine (N), whereas if X12 is aspartate (D) then
- X13 is asparagine (N)
- 18
- K1 is lysine (K)
- 19
- C4 is cysteine
- 20
- T1 is threonine (T)
- 21
- X14 is histidine (H) or tyrosine (Y)
- 22
- G1 is glycine
- 23
- K2 is lysine (K)
- 24
- C5 is cysteine,
- 25
- X15 is methionine (M), threonine (T) or norleucine (Nor),
- 26
- N1 is asparagine,
- 27
- R1 is arginine (R)
- 28
- K3 is lysine
- 29
- C6 is cysteine,
- 30
- X16 is lysine (K) or glycine (G)
- 31
- C7 is cysteine,
- 32
- T1 is threonine,
- 33
- N2 is asparagine (N)
- 34
- C8 is cysteine,
- 35
- X17 is lysine (K) or arginine (R)
150 more elements
Dependencies are inferred from the claim text.