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US 2015/0086553 A1Published application
Polypeptide binding to annexin a1 and use thereof
AssigneeSamsung Electronics Co., Ltd.
InventorsJieun HAN, Jung Min KIM, Jae Il LEE
Life of this patent
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Abstract
A polypeptide binding to Annexin A1, an antagonist against Annexin A1 including the polypeptide, an anti-Annexin A1 antibody including the polypeptide or an antigen-binding fragment thereof, and methods of preventing, treating and/or diagnosing a disease, including administering the antagonist and/or the antibody or an antigen-binding fragment thereof to a subject.
Claims17
An antagonist against Annexin A1 comprising:
- a polypeptide comprising at least one of SEQ ID NO:
- 2 or SEQ ID NO:
- 147;
- a polypeptide comprising at least one of SEQ ID NOs:
- 12 to 42;
- a polypeptide comprising at least one of SEQ ID NO:
- 48, SEQ ID NO:
- 61, SEQ ID NO:
- 63, SEQ ID NO:
- 67, SEQ ID NO:
- 70, SEQ ID NO:
- 73, or SEQ ID NO:
- 148;
- a polypeptide comprising SEQ ID NO:
- 149;
- a polypeptide comprising at least one of SEQ ID NOs:
- 95 to 112;
- a polypeptide comprising at least one of SEQ ID NO:
- 135 or SEQ ID NO:
- 150 (General Formula 4);
- and
- a combination thereof.
19 more elements
An anti-Annexin A1 antibody or an antigen-binding fragment thereof comprising:
- at least one heavy chain complementarity determining region (CDR) selected from the group consisting of CDR-H1 comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 and SEQ ID NO:
- 147, CDR-H2 comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 12 to SEQ ID NO:
- 42, and CDR-H3 comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 48, SEQ ID NO:
- 61, SEQ ID NO:
- 63, SEQ ID NO:
- 67, SEQ ID NO:
- 70, SEQ ID NO:
- 73, and SEQ ID NO:
- 148, or a heavy chain variable region comprising the at least one heavy chain complementarity determining region;
- at least one light chain complementarity determining region selected from the group consisting of CDR-L1 comprising an amino acid sequence of SEQ ID NO:
- 149, CDR-L2 comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 95 to SEQ ID NO:
- 112, and CDR-L3 comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 135 to SEQ ID NO:
- 150, or a light chain variable region comprising the at least one light chain complementarity determining region;
- a combination of the at least one heavy chain complementarity determining region and the at least one light chain complementarity determining region;
- or
- a combination of the heavy chain variable region and the light chain variable region.
18 more elements
Dependencies are inferred from the claim text.