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US 2015/0080721 A1Published application
Detection of tumor microenvironment with chlorotoxin conjugates
AssigneesBlaze Bioscience, Inc., Washington State University
InventorsJulia E. Novak, Stacey J. Hansen, William S. Dernell, Katie C. Kennedy, Valorie R. Wiss
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Abstract
The present disclosure provides methods for detecting a tumor microenvironment, a peritumoral tissue, or a portion thereof using a chlorotoxin conjugate. Also provided are chlorotoxin peptides and variants thereof conjugated to a detectable label for use in detecting a tumor microenvironment, a peritumoral tissue, or a portion thereof.
Claims16
A method of detecting a tumor microenvironment, peritumoral tissue, or cells therefrom, the method comprising the steps of:
- a) administering a chlorotoxin conjugate to the tumor microenvironment, peritumoral tissue, or cells therefrom, wherein the chlorotoxin conjugate binds to the tumor microenvironment, peritumoral tissue, cells therefrom, or a combination thereof;
- and
- b) imaging, visualizing, or analyzing the bound chlorotoxin conjugate.
Dependencies are inferred from the claim text.