RNA-Mediated Gene Modulation
AssigneeUniversity of Southern California
InventorsShi-Lung LIN, Shao-Yao YING
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Abstract
An isolated RNA comprising an intron RNA that is released in a cell, thereby modulating the function of a target gene. Also disclosed are a composition comprising a chemokine and an isolated RNA of the invention or a DNA template for the isolated RNA, a composition comprising one or more agents that induce RNA-mediated modulation of the functions of two or more target genes in a cell, and methods of using these compositions for modulating the functions of genes in a cell.
Claims2
An isolated RNA comprising an intron RNA that is released in a cell, thereby modulating the function of a target gene, wherein the isolated RNA does not contain a combination of a splice donor site that includes 5′-GU(A/G)AGU-3′ and a splice acceptor site that includes 5′-CU(A/G)A(C/U)NG-3′.
2-57. (canceled)
Dependencies are inferred from the claim text.