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US 2015/0031852 A1Published application
Selective delivery molecules and methods of use
AssigneeAvelas Biosciences, Inc.
InventorsJunjie Liu, Jesus Gonzalez
Life of this patent
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Abstract
Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
Claims44
A selective delivery molecule of Formula I, having the structure:
- [DA-cA]-A-[cM-M]-X-B-[cB-DB] Formula I
- wherein,
- X is a cleavable linker;
- A is a peptide with a sequence comprising 5 to 9 acidic amino acids;
- B is a peptide with a sequence comprising 7 to 9 basic amino acids;
- cA, cB, and cM are each independently 0-1 amino acid, wherein the amino acid is a naturally-occurring amino acid or non-naturally-occurring amino acid;
- M is a polyethylene glycol (PEG) polymer;
- and
- DA and DB are each independently an imaging agent;
- and
- wherein [cM-M] is bound to at any position on A or X, [DA-CA] is bound to any amino acid on A or X, and [cB-DB] is bound to any amino acid on B.
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Dependencies are inferred from the claim text.