Rasagiline orally disintegrating compositions

A solid pharmaceutical composition comprising

• a. rasagiline or a pharmaceutically acceptable salt of rasagiline,
• b. a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols,
• c. a supplemental sugar alcohol,
• d. a supplemental flow agent, and
• e. a supplemental disintegrant.

A solid pharmaceutical composition comprising

• (i) 0.9% rasagiline mesylate by weight of the composition;
• 70% by weight of the composition of a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols;
• 21.6% xylitol by weight of the composition;
• 0.2% silicon dioxide by weight of the composition;
• 1.5% crosscarmelose sodium by weight of the composition;
• 2.8% starch by weight of the composition;
• 0.7% flavoring agent by weight of the composition;
• 0.3% sweetener by weight of the composition;
• and
• 2% sodium stearyl fumarate by weight of the composition,
• (ii) 2.1% rasagiline mesylate by weight of the composition;
• 63.3% by weight of the composition of a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols;
• 25.7% xylitol by weight of the composition;
• 0.3% silicon dioxide by weight of the composition;
• 1.7% crosscarmelose sodium by weight of the composition;
• 3.3% starch by weight of the composition;
• 1.1% flavoring agent by weight of the composition;
• 0.5% sweetener by weight of the composition;
• and
• 2% sodium stearyl fumarate by weight of the composition,
• (iii) 3.12 mg rasagiline mesylate;
• 245 mg of a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols;
• 77.276 mg of xylitol;
• 0.6 mg of silicon dioxide;
• 5.25 mg of crosscarmelose sodium;
• 10.0 mg of starch;
• 2.334 mg of a flavoring agent;
• 1.0 mg of a sweetener;
• and
• 6.8 mg of sodium stearyl fumarate, or
• (iv) 3.12 mg rasagiline mesylate;
• 94.75 mg of a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols;
• 38.64 mg of xylitol;
• 0.45 mg of silicon dioxide;
• 2.265 mg of crosscarmelose sodium;
• 5.0 mg of starch;
• 1.665 mg of a flavoring agent;
• 0.75 mg of a sweetener;
• and
• 3.0 mg of sodium stearyl fumarate.