Pharmaceutical composition containing mirabegron
AssigneeAstellas Pharma Inc.
InventorsYuki Kasashima, Keiichi Yoshihara, Yoshitaka Ito, Takatsune Yoshida, Yumi Matsui
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Abstract
Provided is a mirabegron-containing pharmaceutical composition in which the leakage of mirabegron can be inhibited when the pharmaceutical composition is dispersed in a liquid, and in which the change in pharmacokinetics caused by the presence or absence of food intake is decreased. The pharmaceutical composition comprises an acid addition salt of alkyl sulfuric acid and mirabegron, and a base for modified release.
Claims29
A pharmaceutical composition comprising an acid addition salt of alkyl sulfuric acid and mirabegron, and a base for modified release.
A process of manufacturing a pharmaceutical composition, comprising mixing an acid addition salt of alkyl sulfuric acid and mirabegron, with a base for modified release.
A process of manufacturing a pharmaceutical composition, comprising the steps of:
- (1) dissolving mirabegron in a solvent,
- (2) mixing alkyl sulfuric acid into the resulting mixture prepared in (1), and
- (3) mixing a base for modified release into the resulting mixture prepared in (2).
An acid addition salt of alkyl sulfuric acid and mirabegron.
Dependencies are inferred from the claim text.